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Retatrutide Sexual Function Impact: What the Phase 2 Data Actually Show At a glance Drug / retatrutide (LY3437943), investigational triple GIP/GLP-1/glucagon receptor agonist Phase 2 trial / Jastreboff et al., NEJM 2023, N=338 adults with obesity Peak weight loss / 24.2% mean body-weight reduction at 48 weeks (12 mg dose) Sexual-function endpoints / not prespecified in Phase 2

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endurance training on bone mineral density, hip geometry indices and trabecular bone score in a group of young overweight women

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Meanwhile, treatment with 1 mM GSH elicited a threefold increase in the levels of both thiols (Supplementary Table 6)